Updated at 11:40 a.m. ET
A Saratov Airlines plane crashed about 25 miles from Moscow where it took off, evidently killing everyone on board, said Russia's Transport Minister.
The plane disappeared from radar shortly after takeoff from Domodedovo Airport at 2:21 p.m. local time, en route to the Russian city of Orsk located about 1,000 miles southeast, reports the TASS news agency.
There were 65 passengers and six crew members on board, says TASS.